Assay Guidance Manual : Quantitative Biology and Pharmacology in Preclinical Drug Discovery

Toxins in Drug Discovery and Pharmacology

Venoms from marine and terrestrial animals (cone snails, scorpions, spiders, snakes, centipedes, cnidarian, etc.) can be seen as an untapped cocktail of biologically active compounds, being increasingly recognized as a new emerging source of peptide-based therapeutics.

Perspectives in Pharmacology Productivity Shortfalls in Drug Discovery: Contributions from the Preclinical Sciences?

An inverse relationship between human and financial investment and productivity, in the form of new drug approvals, has been a consistent theme in drug discovery for more than a decade. There appear to be many causes and solutions for this, but few tangible outcomes. Although Food and Drug Administration regulators, the constraints resulting from short-term business decisions, and the harvestin...

Pharmacology – Prep Manual for Undergraduates

Introduction to Biochemical Pharmacology and Drug Discovery

Systems Pharmacology in Small Molecular Drug Discovery

Drug discovery is a risky, costly and time-consuming process depending on multidisciplinary methods to create safe and effective medicines. Although considerable progress has been made by high-throughput screening methods in drug design, the cost of developing contemporary approved drugs did not match that in the past decade. The major reason is the late-stage clinical failures in Phases II and...